rPeptide/Alpha-Synuclein, 1-60/S-1011-1/

来自 : 发布时间：2025-04-22

Sequence MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYV GSKTKEGVVHGVATVAEKTK Source Recombinant. A DNA sequence encoding the human alpha-synuclein (1-60) sequence was expressed in E. coli. Description A deletion mutant of α-synuclein (amino acids 1-60), which contains the N-terminal amphipathic domain, ^2,4. Alpha-Synuclein (α-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. α-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. α-Synuclein appears to associate with other proteins that aggregate and is found in β-amyloid plaques and neuritic tangles in Alzheimer’s disease³. Molecular Mass 6,149 Da Purity >95% by SDS-PAGE