This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARSCoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

rPeptide (www.rpeptide.com) 是一家生物化学公司，坐落于美国乔治亚州，与雅典毗邻。该公司研发试剂是市场领跑者，主要 产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白，重组多肽，抗体以及试剂等等。该公司提供一系列外包服务，从分子生物学，蛋白表达与蛋白纯 化到13C与15N 统一标记蛋白与多肽。同时， rPeptide 技术平台可解决可溶性多肽/蛋白（例如：β-淀粉样蛋白、廋蛋白、前胰岛素）在大肠杆菌中表达等历史性难题。 产品清单： 商品名称    商品货号    商品品牌 Beta-Amyloid (1-40), Mouse, Rat    A-1007-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-2    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-1    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-2    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-1    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-2    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-1    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-2    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-1    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-2    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-1    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-2    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-1    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-2    rPeptide