Potent and selective CXCR2 receptor antagonist (IC₅₀ = 22 nM). Displays >150-fold selectivity over CXCR1 receptors¹. Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe². Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence³ and neutrophil chemotaxis¹. Inhibits HIV replication in lymphocytes and macrophages⁴. Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation⁵.

rPeptide (www.rpeptide.com) 是一家生物化学公司，坐落于美国乔治亚州，与雅典毗邻。该公司研发试剂是市场领跑者，主要 产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白，重组多肽，抗体以及试剂等等。该公司提供一系列外包服务，从分子生物学，蛋白表达与蛋白纯 化到13C与15N 统一标记蛋白与多肽。同时， rPeptide 技术平台可解决可溶性多肽/蛋白（例如：β-淀粉样蛋白、廋蛋白、前胰岛素）在大肠杆菌中表达等历史性难题。 产品清单： 商品名称    商品货号    商品品牌 Beta-Amyloid (1-40), Mouse, Rat    A-1007-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-2    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-1    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-2    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-1    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-2    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-1    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-2    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-1    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-2    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-1    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-2    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-1    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-2    rPeptide