Angiotensin II converting enzyme (ACE2, EC 3.4.17.23), a zinc-based metalloprotease is part of the renin-angiotensin system (RAS) that controls the regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of lung, kidney and heart. ACE2 is a potential therapeutic target for cardiovascular and coronavirus-induced diseases. This ACE2 Activity Assay Kit kit will help the research progress in this field. This kit utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. We also provide an ACE2 specific inhibitor that can differentiate the ACE2 activity from other proteolytic activity.The kit can detect as low as 0.4 mU. Our assay kit is simple and can be used in a high-throughput format.

rPeptide (www.rpeptide.com) 是一家生物化学公司，坐落于美国乔治亚州，与雅典毗邻。该公司研发试剂是市场领跑者，主要 产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白，重组多肽，抗体以及试剂等等。该公司提供一系列外包服务，从分子生物学，蛋白表达与蛋白纯 化到13C与15N 统一标记蛋白与多肽。同时， rPeptide 技术平台可解决可溶性多肽/蛋白（例如：β-淀粉样蛋白、廋蛋白、前胰岛素）在大肠杆菌中表达等历史性难题。 产品清单： 商品名称    商品货号    商品品牌 Beta-Amyloid (1-40), Mouse, Rat    A-1007-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-2    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-1    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-2    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-1    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-2    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-1    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-2    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-1    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-2    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-1    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-2    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-1    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-2    rPeptide