SARS-CoV-2 & SARS-CoV belong to the family of Coronaviridae and are characterized by large positive-sense RNA genome, that is about 30 kb in length. One unique feature of SARS-CoV-2 & SARS-CoV is that two-thirds of the viral genome is translated into two large polyproteins whereas the remaining viral genome is transcribed into sub-genomic RNAs. The two large polyproteins encode multiple non-structural proteins that play an important role in viral replication and transcription. SARSCoV-2 & SARS-CoV transcribe multiple sub-genomic RNAs that encode four structural proteins, namely, envelope (E), membrane (M), spike (S), and nucleocapsid (N). Some of the main functions of the nucleocapsid protein are 1) to package the genomic of the virus into long and helical ribonucleoprotein (RNP) complexes, 2) to dimerize and associate with genomic RNA of the virus, as well as interact with other structural proteins of the virus, both of which functions are essential for viral assembly, 3) associate with ER-Golgi complex during virus budding, 4) assist in genomic RNA synthesis, 5) assist RNA chaperone proteins in proper folding of nucleic acids, and 6) play an important role in viral pathogenesis.

rPeptide (www.rpeptide.com) 是一家生物化学公司，坐落于美国乔治亚州，与雅典毗邻。该公司研发试剂是市场领跑者，主要 产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白，重组多肽，抗体以及试剂等等。该公司提供一系列外包服务，从分子生物学，蛋白表达与蛋白纯 化到13C与15N 统一标记蛋白与多肽。同时， rPeptide 技术平台可解决可溶性多肽/蛋白（例如：β-淀粉样蛋白、廋蛋白、前胰岛素）在大肠杆菌中表达等历史性难题。 产品清单： 商品名称    商品货号    商品品牌 Beta-Amyloid (1-40), Mouse, Rat    A-1007-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-2    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-1    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-2    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-1    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-2    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-1    rPeptide Beta-Amyloid (1-40, Scrambled)    A-1003-2    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-1    rPeptide Beta-Amyloid (1-40, Y10W)    A-1012-2    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-1    rPeptide Beta-Amyloid (1-42), Mouse, Rat    A-1008-2    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-1    rPeptide Beta-Amyloid (1-42), Starter Kit    A-1160-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HCl    A-1166-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, HFIP    A-1163-2    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-1    rPeptide Beta-Amyloid (1-42), Ultra Pure, NaOH    A-1165-2    rPeptide